Dr. David Sinclair's Daily Routine

Dr. David Sinclair on Coconut Oil Pulling:

“I’ll start by rinsing my mouth with coconut oil—pulling it—that improves my mouth microbiome.”

Coconut oil pulling benefits:

• Enhances oral health by reducing harmful bacteria, preventing gingivitis, and freshening breath.
• May contribute to teeth whitening and removal of stains.
• Potential for detoxification, improved skin complexion, and anti-inflammatory effects, although more research is needed to confirm these benefits.

Dr. David Sinclair on Toothpaste Choices:

“I brush my teeth with nontoxic toothpaste”

Benefits of Non-Toxic Toothpaste:

• Gentle on teeth and gums, making it ideal for sensitive individuals.

Free from harmful chemicals such as parabens, sulfates, and artificial dyes, reducing health risks.

• Environmentally conscious, with eco-friendly packaging, benefiting both oral and environmental health.
• Allergy-friendly, featuring reduced synthetic ingredients and ensuring safety for children and those with sensitivities.

Dr. David Sinclair on his Supplement Stack:

“I go down to the kitchen and have a little bit of yogurt with some polyphenols. The one I’ve talked about a lot is resveratrol. Now, it’s just a couple of mouthfuls of yogurt so it’s not going to break my fast and it’s not considered breakfast by any means. But it is how I get all my polyphenols in and they dissolve—I’ve been doing that for about 15 years.”

Dr. David Sinclair on Resveratrol

‍“One resveratrol is a small, what's called a polyphenol. It's produced by many plants to survive. It's produced by grapes and it's concentrated in red wine. It should be a white powder; it shouldn't be brown. If you buy it and it's brown, throw it away. I take a gram of it every morning, with rare exceptions when I'm traveling and I forget it, but I mix it with a little bit of yogurt because it's just a little bit like a couple of teaspoons.”

Dr. David Sinclair on NAD (Life Extension)

“The doubling of that NAD is important because as we get older, we make less of this chemical. We have about half the levels of NAD in our skin, for example, as I have about half the levels I would have made when I was 20. So, I boost those levels back up to being youthful, and the idea is that the body's defenses are activated.” 

Dr. David Sinclair on his Morning Supplements

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Athletic Green AG1

“Now, the third supplement I mentioned is Athletic Greens. Because I'm on a vegetarian/vegan diet, which I describe as being a newbie struggling vegan, I need to ensure I get all the necessary nutrients. Athletic Greens is full of vitamins and plant-based whole foods that ensure I don't lack those nutrients. When you're on a vegan diet and have also given up dairy, it's crucial to make sure there's adequate nutrition.”

“I typically follow a one-meal-a-day (OMAD) pattern, but I want to add another couple of letters to that, making it ANOMAD (Adequate Nutrition One Meal A Day). I just made that up, by the way, so consider it trademarked. Adequate nutrition is key, and that's what Athletic Greens provides for me.”

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Nicotinamide mononucleotide (NMN): 1g per day, in the morning.

To improve absorption, David combines NMN supplements with olive oil or natural yogurt.

NMN acts as a precursor to NAD+, a molecule vital for cellular metabolism and sustaining youthful levels in the body. Dr. David Sinclair utilizes NMN to promote NAD+ production and potentially extend the aging process.

Resveratrol: 1g per day, in the morning.

David combines 1000mg of Resveratrol with olive oil and consumes it each morning. This combination complements NMN by activating Sirtuin genes and aiding in DNA repair processes.

Spermidine: 1 mg per day, in the morning.

Spermidine is present in foods such as cheese, legumes, mushrooms, and soy, influencing aging processes. It has links to a decreased risk of neurodegenerative diseases, cardiovascular issues, and cancer-related mortality in humans.

Quercetin and Fisetin: 500 mg each, once per day, in the morning.

Quercetin and Fisetin have the ability to eliminate senescent cells, which are cells that resist dying. These potent flavonoids act as antioxidants and are recognized for their capacity to decrease inflammation and tissue damage associated with aging.

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Additional Supplements

Vitamin D3: 4,000 to 5,000 IU per day.

Vitamin D is vital for various bodily processes, including bone health and immunity. Vitamin D deficiency is common, and symptoms like fatigue, hair loss, sleep disturbances, and bone pain may indicate the need for vitamin D supplementation.

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Vitamin K2: 180 to 360 micrograms per day.

Vitamin K2 plays a significant role in bone and mitochondrial health. It can be naturally obtained from sources like leafy greens, whole grains, and natural oils.

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Statin:

Dr. David Sinclair has been using Statin since the age of 29 and now maintains the heart health of a 20-year-old. However, it's crucial to emphasize that Statin may not be suitable for everyone, He uses it because his family has a history of heart problems.

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Low-dose aspirin: 85 mg per day.

Dr. David Sinclair consumes a daily dose of 85 mg of Aspirin, potentially for heart stroke protection. However, it's vital to exercise caution with large Aspirin doses due to the risk of bleeding.

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TMG (Trimethylglycine or betaine): 500 mg to 1,000 mg per day

TMG, or Trimethylglycine is a naturally occurring compound, also known as betaine, plays a crucial role in supporting several biochemical processes within the body. It acts as a methyl group donor, facilitating essential functions like liver health and cellular replication.

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Omega 3

Omega-3 fatty acids play a crucial role in heart health and cognitive function. Omega-3 supplementation may help mitigate signs of aging by maintaining skin hydration and reducing inflammation. It's important to note that daily omega-3 intake should not exceed 3 grams to prevent potential side effects like low blood pressure and diarrhea.

Hot Water With Lemon 

“And then I have hot water with lemon.”

Benefits of Hot Water With Lemon

Lemons are a vitamin C powerhouse, and many find benefits in drinking hot water with lemon slices, such as improved complexion, reduced bloating, and detoxification.

Matcha Tea

Dr. David Sinclair's choice for a caffeine source is Green Matcha Tea.

“Then I have a Green Matcha Tea, which is full of healthy polyphenols like ECGC catechins—and that's a cancer-preventative—so I have at least one of those, maybe two”

Benefits of Matcha Tea 

Matcha contains more catechins than regular green tea, serving as natural antioxidants. This can aid in reducing cell damage and preventing age-related diseases. Matcha may also enhance brain function, support heart health, and contribute to liver protection.

Dr. David Sinclair on Intermittent Fasting

“Yes. I think three meals a day plus snacks is too much. It puts the body in a state of abundance, which turns off our longevity genes. So you want to have a period of fasting each day starting as early as your 20s. But if you’re younger, we don’t want malnutrition or starvation, that’s not the point. But you want to take-in your nutrition and your calories in a certain window. The one that I try to go for is 16 to 18 hours without eating a large meal. That’s basically having a very late lunch or large dinner”

Recommends Three Types of Intermittent Fasting:

“You’re an individual, you’ve got a different lifestyle, tolerance for pain and hunger, and microbiome—these are really important things to take into consideration,”

1. Extended fasting

“These extended periods are going to do a real deep clean of the body and turn on that autophagy. Especially once you pass the three-day mark, when your metabolism switches into what’s called chaperone-mediated autophagy—also known as the deep cleanse.”

2. Time-Restricted Feeding

“You want to have at least 16 hours of not eating or not eating very much,” 

“So typically that means having a late lunch if you skip breakfast, or if you prefer to skip dinner, you can skip that.”

3. Fasting-mimicking diet

The "fasting-mimicking diet" has demonstrated advantages for cancer patients during chemotherapy.

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Dr. David Sinclair’s diet entails a monthly five-day calorie restriction (1,100 calories per day), focusing on plant-based, low-carb, low-protein, and high-healthy-fat foods, replicating the physiological response to fasting. According to Dr. David Sinclair, the key element is reducing meat intake to suppress mTOR.

Dr. David Sinclair on Maintaining Work Productivity and Health

• “Then I go to work at a standing desk—I have a standing desk in my office at Harvard and I have one at home as well—and I do my best not to sit down throughout the day. I will continuously drink water and hot tea throughout the day until dinner.”

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Dr. David Sinclair on the Future of Preventative Health

“In the near future, cancer, heart disease, and type 2 diabetes will be largely preventable and increasingly curable,”

Dr. David Sinclair on Maximizing Workouts for Health and Longevity

• Elevate the heart and respiratory rate during exercise.
• Opt for higher-intensity workouts, with a preference for HIIT (High-Intensity Interval Training).
• Focus on controlled, deep, and rapid breathing, maintaining it at around 70-85% of the maximum heart rate. This facilitates increased oxygen flow into the bloodstream and boosts calorie expenditure, thereby activating the Epigenetic clock.
• Engage in challenging workouts that make it challenging to speak more than a few words without needing to pause for breath, inducing a hypoxic response.
• Incorporate cold-weather workouts to enhance immune system function.

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Dr. David Sinclair on his Workout Habits 

“Before the pandemic, I was doing a lot of gym exercise—running on the treadmill and doing weights. After that, I’ve fallen a bit off the wagon. I don’t exercise every day. I have weights at home in my bedroom and a gym in my bedroom that I use. Ideally, I aim for three times a week to do some weights, and if I don’t go for a run, I go for a walk. I would say that my biggest challenge right now is to get moving”

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What Does Dr. David Sinclair Eat?

“That dinner would be a plant-based, nut-based dinner with rice, almonds, couscous, or crushed cassava. I love what I eat—as much as when I used to eat meat.”

“Adequate nutrition is necessary because otherwise you’re going to be doing your body more harm than good,” 

Dr. David Sinclair on his Dietary Transformation

“A plant-focused diet. I rarely, rarely eat anything other than plant-based and nut-based foods, including milk. I’m off dairy and I’m off alcohol as well. Very rarely will I eat any or drink any of those things, but on occasion for a celebration or whatever I’m happy to do that, but that’s what I focus on. That’s made a huge difference to my blood biomarkers and epigenetic age. In just a matter of months, I was able to further reduce my biological age by eating better.”

“Before that, I was on a red wine and cheese-based diet, which was not conducive to health as much. It’s good to know though that the recent data on alcohol is showing that even one glass a day of alcohol is going to affect your brain cells.”

Dr. David Sinclair on Benefits of the new diet

“It’s sad, though when I switched to this new diet, I got my memory back as well. I was unable to remember phone numbers and key codes easily, and now it’s simple. So I got back to my 20-year-old brain. I just thought it was old age, but it wasn’t, it was my lifestyle.”

Dr. David Sinclair on his Evening Supplement

“I do take one other medication, called metformin, which is a type 2 diabetes drug that has been associated with longer life and fewer age-related diseases. Studies have shown that type 2 diabetics who take metformin, typically at two grams a day (I'm on one gram a day), actually have fewer diseases and live longer than people who don't have type 2 diabetes.”

Dr. David Sinclair on his Sleep Routine

"Normally I am asleep by 12 and monitor I’m getting seven hours by wearing an Oura Ring. I have the Eight Sleep bed, which controls the temperature throughout the night to get me quickly to deep sleep."

“I try to get at least six hours of sleep a night, and sometimes I’m successful, but I would say that’s something I need to work on. I would prefer to get seven to eight, but I can get by with six. I sleep on a bed that adjusts my body temperature while I’m asleep to get the deepest of sleep—it lowers your body temperature and then warms you back up toward the morning. It monitors my heart rate through the night and so I see how I’ve done. I also wear a ring that tells me similar information.”